Expression of Lef1 in vole tooth

expression of lymphoid enhancer factor 1 in diastema bud; lymphoid enhancer binding factor 1; transcription factor, T-cell specific, 1 alpha (Tcf1 alpha)

Species: vole
Tooth: molar
Method: in situ hybridization (radioactive), probe: 660b


Initiation stage
Expression: dental epithelium, dental mesenchyme
No expression: oral epithelium

Bud stage
Expression: dental epithelium, dental mesenchyme
No expression: oral epithelium

Cap stage
Expression: enamel knot, dental papilla, dental sac
No expression: oral epithelium, outer enamel epithelium, stellate reticulum

Bell stage
Expression: inner enamel epithelium, dental papilla, dental sac
No expression: oral epithelium, outer enamel epithelium, stratum intermedia, stellate reticulum

Mouse null mutants of Lef1 do not develop teeth.
Lef1expression in the enamel knot is necessary for tooth development.

Source references:
Keränen,S.V.E., Åberg,T., Kettunen,P., Thesleff,I., and, Jernvall,J. (1998) Development Genes & Evolution 208(9):477-486

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Data last edited 05.04.2004 by M.K., page last created 10.12.2004 by P.N.