Expression of Eda in mouse tooth

Eda; ectodysplasin A; Tabby; Ed1

Species: mouse
Location in mouse genome: chromosome X, 89812368 - 90237478 (UCSC, assembly October 2003)
Tooth: lower molar
Method: in situ hybridization (radioactive), probe: 1836b

Initiation stage
Expression: oral epithelium
No expression: dental epithelium, dental mesenchyme

EDA expression in epithelium was induced by Wnt6 expressing cells (Laurikkala et al 2001). See expression of Wnt6.

Bud stage
Expression: oral epithelium, dental epithelium
No expression: dental mesenchyme

Cap stage
Expression: oral epithelium, outer enamel epithelium
No expression: inner enamel epithelium, enamel knot, stellate reticulum, dental papilla, dental sac

Bell stage
Expression: outer enamel epithelium
No expression: inner enamel epithelium, stratum intermedia, stellate reticulum, dental papilla

Late bell
(differentiation) stage
Expression: outer enamel epithelium
No expression: stratum intermedia, stellate reticulum, preameloblasts, dental papilla, preodontoblasts

Supernumerary teeth and abnormal molars and enamel in incisors in mice with K14-EDA-overexpression. (Mustonen et al 2003)
EDA gene encodes a tumor necrosis factor family ligand ectodysplasin.
Human homolog: EDA (anhidrotic ectodermal dysplasia).
Tabby mouse has mutations in EDA.
Mutations in EDA cause X-linked anhidrotic ectodermal dysplasia (EDA).
Probe recognizes all splicing forms of Tabby.

Source references:
Laurikkala,J., Mikkola,M., Mustonen,T., Åberg,T., Koppinen, Pispa,J., Nieminen,P., Galceran,J., Grosschedl,R., and, Thesleff,I. (2001) Developmental Biology 229(2):443-455

Other references:
Mikkola,M.L., Pispa,J., Pekkanen,M., Paulin,L., Nieminen,P., Kere,J., and, Thesleff,I. (1999) Mechanisms of Development 88(2):133-146
Srivastava,A.K., Pispa,J., Hartung,A.J., Du,Y., Ezer,S., Jenks,T., Shimada,T., Pekkanen,M., Mikkola,M., Ko,M.S.H., Thesleff,I., Kere,J., and, Schlessinger,D. (1997) Proceedings of the National Academy of Sciences of the United States of America 94:13069-13074
Tucker,A.S., Headon,D.J., Schneider,P., Ferguson,B.M., Overbeek,P., Tschopp, J, and, Sharpe,P.T. (2000) Development 127(21):4691-4700

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Data last edited 03.02.2001 by M.P., page last created 10.12.2004 by P.N.