Expression of Pitx2 in mouse tooth

paired-like homeodomain transcription factor 2; Otlx2; ried bicoid related homeobox transcription factor 1 (RIEG1); pituitary homeobox 2 (Ptx2); solurshin; All1 responsive gene (Arp1); Munc30

Species: mouse
Location in mouse genome: chromosome 3, 132812431 - 132832072 (UCSC, assembly October 2003)
Method: in situ hybridization (radioactive), probe: 535nt

Initiation stage
Expression: oral epithelium, dental epithelium
No expression: dental mesenchyme

In Pitx2 null mutant mice tooth development is arrested at bud stage.
Mutations in PITX2 gene cause Rieger syndrome.

Source references:
Semina,E.V., Reiter,R., Leysens,N.J., Alward,W.L.M., Small,K.W., Datson,N.A.X.S.J., Bierkenelson,D., Bitoun,P., Zabel,B.U., Carey,J.C., Murray, and, JC. (1996) Nature Genetics 14(4):392-399

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Data last edited 05.04.2004 by M.K., page last created 10.12.2004 by P.N.