Expression of Prrx2 in mouse tooth |
| Prrx2; paired related homeobox 2; Prx2; S8 |
| Species: mouse |
| Tooth: molar and incisor |
| Method: in situ hybridization (radioactive), probe: 575nt, 200nt |
Initiation stage | |
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Expression: dental mesenchyme No expression: oral epithelium, dental epithelium | |
Bud stage | |
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Expression: dental mesenchyme No expression: oral epithelium, dental epithelium |
Cap stage | |
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Expression: dental papilla, dental sac No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, enamel knot, stellate reticulum |
Bell stage | |
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Expression: dental papilla, dental sac No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stratum intermedia, stellate reticulum |
| Transgenic mice deficient in both Prx1 and Prx2 lack mandibular incisors. The development is arrested within bud stage as a single incisor bud.. |
| Source references: |
| Opstelten,D.J., Vogels,R., Robert,B., Kalkhoven,E., Zwartkruis,F., de Laaf,L., Destrée,O.H., Deschamps,J., Lawson,K.A., and, Meijlink,F. (1991) Mechanisms of Development 34(1):29-41 |
| Karg,H., Burger,E.H., Lyaruu,D.M., Bronckers,A.L., and, Wöltgens,J.H. (1997) Archives of Oral Biology 42(9):625-631 |
| Lu,M.F., Cheng,H.T., Kern,M.J., Potter,S.S., Tran,B., Diekwisch,T.G.H., Martin, JF., Jmartin@ibt.tamu.edu, Paired-related homeobox, Craniofacial development, Genetic redundancy, Mouse, and, Prx-1. (1999) Development 126(3):495-504 |