Expression of Pax9 in mouse tooth |
| paired box gene 9 |
| Species: mouse |
| Location in mouse genome: chromosome 12, 52044805 - 52060366 (UCSC, assembly October 2003) |
| Tooth: molar and incisor |
| Method: in situ hybridization (radioactive), probe: |
Initiation stage | |
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Expression: dental mesenchyme No expression: oral epithelium, dental epithelium FGF8 (in beads) induced Pax9 expression in dental mesenchyme in tissue culture (Neubüser et al 1997). See expression of Fgf8. BMP4 (in beads) repressed induction of Pax9 by FGF8 (in beads) in dental mesenchyme in tissue culture (Neubüser et al 1997). See expression of Bmp4. No Pax9 expression detected in mandibular mesenchyme before embryonic day 10. At E10 Pax9 expression was detected laterally in the prospective sites of molar formation and in the medial nasal processes.. |
Bud stage | |
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Expression: dental mesenchyme No expression: oral epithelium, dental epithelium |
Cap stage | |
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Expression: dental papilla No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, enamel knot, stellate reticulum, dental sac |
Bell stage | |
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Expression: dental papilla No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stratum intermedia, stellate reticulum, dental sac | |
| Bmp4 expression was reduced in the dental mesenchyme in Pax9 null mutant mice. (Peters et al 1998) See expression of Bmp4. |
| Msx1 expression was reduced in the dental mesenchyme in Pax9 null mutant mice. (Peters et al 1998) See expression of Msx1. |
| in Pax9 null mutant mice, tooth development is arrested at bud stage. |
| Mutations in PAX9 cause oligodontia (severe congenital tooth agenesis). |
| Source references: |
| Neubüser,A., Peters,H., Balling,R., and, Martin,G.R. (1997) Cell 90(2):247-255 |
| Peters,H., Neubüser,A., Kratochwil,K., and, Balling,R. (1998) Genes & Development 12(17):2735-2747 |
| Ċberg,T., Wang,X.P., Kim,J.H., Yamashiro,T., Bei,M., Rice,R., Ryoo,H.M., and, Thesleff,I. (2004) Developmental Biology 270(1):76-93 |