Expression of Trp63 in mouse tooth

transformation related protein 63; Ket; p63; p73L; TAp63; Trp53rp1

Species: mouse
Tooth: molar and incisor
Method: whole mount in situ hybridization, probe:

Initiation stage
Expression: oral epithelium, dental epithelium
No expression: dental mesenchyme

p63-deficient transgenic mice lack teeth, hair and hindlimbs.
Mutations in p63 cause EEC syndrome type 3.

Source references:
Mills,A.A., Zheng,B.H., Wang,X.J., Vogel,H., Roop,D.R., and, Bradley,A. (1999) Nature 398(6729):708-713
Yang,A., Schweitzer,R., Sun,D.Q., Kaghad,M., Walker,N., Bronson,R.T., Tabin, C, Sharpe,A., Caput,D., Crum,C., and, McKeon,F. (1999) Nature 398(6729):714-718

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Data last edited 05.04.2004 by M.K., page last created 10.12.2004 by P.N.