Expression of Notch1 in mouse tooth

translocation associated Notch homolog (Tan1)

Species: mouse
Location in mouse genome: chromosome 2, 26724631 - 26770242 (UCSC, assembly October 2003)
Tooth: lower molar
Method: in situ hybridization (radioactive), probe:


Initiation stage
Expression: dental epithelium
No expression: oral epithelium, dental mesenchyme

Bud stage
Expression: dental epithelium
No expression: oral epithelium, dental mesenchyme

Protein was also localized in the epithelium..

Cap stage
Expression: outer enamel epithelium, stellate reticulum, dental papilla
No expression: oral epithelium, inner enamel epithelium, enamel knot, dental sac

Protein was also localized in the epithelium..
Discrepancy in the expression pattern between reports..

Bell stage
Expression: outer enamel epithelium, inner enamel epithelium, stratum intermedia, stellate reticulum
No expression: oral epithelium, dental papilla, dental sac

Late bell
(differentiation) stage
Expression: stratum intermedia
No expression: outer enamel epithelium, stellate reticulum, preameloblasts, dental papilla, dental sac, preodontoblasts

Secretory stage
Expression: stratum intermedia
No expression: outer enamel epithelium, stellate reticulum, ameloblasts, dental papilla, dental sac, odontoblasts

Notch1 expression is downregulated in incisor and molar epithelium of IKKA -/- mouse. (Ohazama et al 2004) See expression of IKKA.

Source references:
Mitsiadis,T.A., Lardelli,M., Lendahl,U., and, Thesleff,I. (1995) Journal of Cell Biology 130(2):407-418

Other references:
Mustonen,T., Tummers,M., Mikami,T., Itoh,N., Zhang,N., Gridley,T., and, Thesleff,I. (2002) Developmental Biology 248(2):281-293

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Data last edited 10.12.2004 by M.K., page last created 10.12.2004 by P.N.