Expression of midkine in mouse tooth

Mdk; neurite growth promoting factor 2 (Negf2); MK

Species: mouse
Location in mouse genome: chromosome 2, 92545833 - 92548288 (UCSC, assembly October 2003)
Tooth: lower molar
Method: immunochemistry, antibody: polyclonal


Initiation stage
Expression: oral epithelium, dental epithelium, basement membrane, dental mesenchyme

Bud stage
Expression: dental epithelium, basement membrane, dental mesenchyme
No expression: oral epithelium

Cap stage
Expression: outer enamel epithelium, inner enamel epithelium, enamel knot, stellate reticulum, basement membrane, dental papilla
No expression: oral epithelium, dental sac

Bell stage
Expression: inner enamel epithelium, basement membrane, dental papilla
No expression: oral epithelium, outer enamel epithelium, stratum intermedia, stellate reticulum, dental sac

Late bell
(differentiation) stage
Expression: stratum intermedia, preameloblasts, basement membrane, dental papilla, preodontoblasts
No expression: outer enamel epithelium, stellate reticulum, dental sac

Secretory stage
Expression: predentin
No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, ameloblasts, enamel, dental papilla, dental sac, odontoblasts


Source references:
Mitsiadis,T.A., Muramatsu,T., Muramatsu,H., and, Thesleff,I. (1995) Journal of Cell Biology 129(1):267-281

Other references:
Mitsiadis,T.A., Salmivirta,M., Muramatsu,T., Muramatsu,H., Rauvala,H., Lehtonen,E., Jalkanen,M., and, Thesleff,I. (1995) Development 121(1):37-51

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Data last edited 05.04.2004 by M.K., page last created 10.12.2004 by P.N.