Expression of Hgf in mouse tooth |
hepatocyte growth factor; scatter factor (Sf); lung fibroblast derived mitogen; hepatopoietin A |
Species: mouse |
Location in mouse genome: chromosome 5, 14486998 - 14552413 (UCSC, assembly October 2003) |
Tooth: molar |
Method: in situ hybridization (radioactive), probe: 449b |
Cap stage | |
No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, enamel knot, stellate reticulum, dental papilla, dental sac | |
Bell stage | |
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Expression: dental papilla No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stratum intermedia, stellate reticulum, dental sac |
Late bell (differentiation) stage | |
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Expression: dental papilla No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, preameloblasts, dental sac, preodontoblasts |
HGF is the ligand of the c-met receptor. |
Antisense inhibition of HGF in vitro results in impaired tooth morphogenesis (Tabata et al., 1996). |
Source references: |
Sonnenberg,E., Weidner,K.M., and, Birchmeier,C. (1993) EXS 65:381-394 |
Other references: |
Tabata,M.J., Kim,K., Yamashita,K., Matsumura,T., Kato,J., Iwamoto,M., Walkisaka,S., Matsumoto,K., Nakamura,T., Kumegawa,M., and, Kurisu,K. (1996) Development 122:1243-1251 |
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