Expression of Gli3 in mouse tooth

Gli-kruppel family member 3

Species: mouse
Location in mouse genome: chromosome 13, 15273967 - 15544980 (UCSC, assembly October 2003)
Tooth: molar and incisor
Method: in situ hybridization (radioactive), probe:

Initiation stage
Expression: oral epithelium, dental epithelium, dental mesenchyme

Bud stage
Expression: oral epithelium, dental mesenchyme
No expression: dental epithelium

Cap stage
Expression: oral epithelium, stellate reticulum, dental papilla, dental sac
No expression: outer enamel epithelium, inner enamel epithelium, enamel knot

Tooth development is arrested after initiation in transgenic mice lacking both Gli2 and Gli3..

Source references:
Hardcastle,Z., Mo,R., Hui,C.C., and, Sharpe,P.T. (1998) Development 125(15):2803-2811

Other references:
Dassule,H.R., and, McMahon,A.P. (1998) Developmental Biology 202(2):215-227

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Data last edited 24.03.1999 by M.P., page last created 10.12.2004 by P.N.