Expression of Fgf4 in mouse tooth |
| fibroblast growth factor 4; kaposi sarcoma oncogene (Kfgf); heparin secretory transforming protein 1 (Hstf1); oncogene Hst |
| Species: mouse |
| Location in mouse genome: chromosome 7, 136923512 - 136924949 (UCSC, assembly October 2003) |
| Tooth: lower molar and incisor |
| Method: in situ hybridization (radioactive), probe: 620b, |
Initiation stage | |
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No expression: oral epithelium, dental epithelium, dental mesenchyme | |
Bud stage | |
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Expression: dental epithelium No expression: oral epithelium, dental mesenchyme |
Cap stage | |
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Expression: enamel knot No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stellate reticulum, dental papilla, dental sac Expression was in enamel knots.. In incisors expression was not seen after cap stage.. Fgf4 expression is lost in the enamel knot in the Lef1 null mutant mouse (Kratochwil et al 2002). See expression of Lef1. Fgf4 expression is a direct target of and positively regulated by Lef1 (Kratochwil et al 2002). See expression of Lef1. FGF4 (in beads) induce Fgf3 expression in cultured dental mesenchyme (Kratochwil et al 2002). See expression of Fgf3. |
Bell stage | |
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Expression: inner enamel epithelium No expression: oral epithelium, outer enamel epithelium, stratum intermedia, stellate reticulum, dental papilla, dental sac Expression was in enamel knots.. |
Late bell (differentiation) stage | |
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No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, preameloblasts, dental papilla, dental sac, preodontoblasts Expression was in enamel knots.. |
| Source references: |
| Kettunen,P., and, Thesleff,I. (1998) Developmental Dynamics 211(3):256-268 |
| Jernvall,J., Kettunen,P., Karavanova,I., Martin,L.B., and, Thesleff,I. (1994) International Journal of Developmental Biology 38(3):463-469 |
| Other references: |
| Vaahtokari,A., Åberg,T., and, Thesleff,I. (1996) Development 122(1):121-129 |
| Åberg,T., Wang,X.P., Kim,J.H., Yamashiro,T., Bei,M., Rice,R., Ryoo,H.M., and, Thesleff,I. (2004) Developmental Biology 270(1):76-93 |