Expression of Fgf3 in mouse tooth |
| fibroblast growth factor 3; Int2 |
| Species: mouse |
| Location in mouse genome: chromosome 7, 136943461 - 136947743 (UCSC, assembly October 2003) |
| Tooth: molar |
| Method: in situ hybridization (radioactive), probe: 500b |
Initiation stage | |
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No expression: oral epithelium, dental epithelium, dental mesenchyme | |
Bud stage | |
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Expression: dental epithelium, dental mesenchyme No expression: oral epithelium |
Cap stage | |
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Expression: enamel knot, dental papilla No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stellate reticulum, dental sac Fgf3 expression is lost in the enamel knot and dental mesenchyme in the Lef1 null mutant mouse (Kratochwil et al 2002). See expression of Lef1. FGF4 (in beads) induce Fgf3 expression in cultured dental mesenchyme (Kratochwil et al 2002). See expression of Fgf4. |
Bell stage | |
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Expression: dental papilla No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stratum intermedia, stellate reticulum, dental sac |
Late bell (differentiation) stage | |
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Expression: dental papilla, preodontoblasts No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, preameloblasts, dental sac |
| Fgf3 expression was absent in the dental mesenchyme in Runx2 null mutant mice. (Åberg et al 2004) See expression of Runx2. |
| Source references: |
| Kettunen,P., Laurikkala,J., Itaranta,P., Vainio,S., Itoh,N., and, Thesleff,I. (2000) Developmental Dynamics 219(3):322-332 |
| Other references: |
| Bei,M., and, Maas,R. (1998) Development 125(21):4325-4333 |
| Wilkinson,D.G., Bhatt,S., and, McMahon,A.P. (1989) Development 105(1):131-136 |