Expression of Fgf10 in mouse tooth

fibroblast growth factor 10

Species: mouse
Location in mouse genome: chromosome 13, 117564554 - 117641637 (UCSC, assembly October 2003)
Tooth: lower molar
Method: in situ hybridization (radioactive), probe: 584b, 750b


Initiation stage
No expression: oral epithelium, dental epithelium, dental mesenchyme

At E10 (before morphological formation), expr. observed in the presumptive dental epithelium and in the adjacent dental mesenchyme..

Bud stage
Expression: dental mesenchyme
No expression: oral epithelium, dental epithelium

Expression in the mesenchyme on the buccal and lingual side of the molar tooth and in the mesenchyme under oral epithelium..

Cap stage
Expression: dental papilla, dental sac
No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, enamel knot, stellate reticulum

Fgf10 expression is lost in dental mesenchyme in the Lef1 null mutant mouse (Kratochwil et al 2002). See expression of Lef1.

Bell stage
Expression: dental papilla
No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stratum intermedia, stellate reticulum, dental sac

Late bell
(differentiation) stage
Expression: dental papilla, preodontoblasts
No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, preameloblasts, dental sac


Source references:
Kettunen,P., Laurikkala,J., Itaranta,P., Vainio,S., Itoh,N., and, Thesleff,I. (2000) Developmental Dynamics 219(3):322-332

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Data last edited 31.01.2001 by M.P., page last created 10.12.2004 by P.N.