Expression of EGFR in human tooth |
| epidermal growth factor receptor; ERBB1 |
| Species: human |
| Location in human genome: chromosome 7, 54828553 - 55016774 (UCSC, assembly October 2003) |
| Method: in situ hybridization (radioactive), probe: 1,84kb |
Cap stage | |
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Expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, dental sac No expression: enamel knot, stellate reticulum, basement membrane, dental papilla |
Bell stage | |
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Expression: outer enamel epithelium, inner enamel epithelium, stratum intermedia, dental sac No expression: oral epithelium, stellate reticulum, basement membrane, dental papilla |
Late bell (differentiation) stage | |
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Expression: outer enamel epithelium, stratum intermedia No expression: stellate reticulum, preameloblasts, basement membrane, dental papilla, dental sac, preodontoblasts Stellate reticulum negative by RISH and positive by immunocytochemistry.. |
Secretory stage | |
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Expression: outer enamel epithelium, stratum intermedia No expression: stellate reticulum, ameloblasts, enamel, dental papilla, dental sac, odontoblasts, predentin Stellate reticulum negative by RISH and weakly positive by immunocytochemistry.. Expression lost in epithelium as matrix deposition progresses. |
| No dental defects noted in transgenic mice lacking EgfR expression (Miettinen et al., 1995). |
| Discrepancy between reports. |
| Source references: |
| Heikinheimo,K., Voutilainen,R., Happonen,R.P., and, Miettinen,P.J. (1993) International Journal of Developmental Biology 37(3):387-396 |
| Other references: |
| Cobo,J., Hernández,L.C., del Valle,M.E., Vijande,M., and, Vega,J.A. (1992) European Journal of Orthodontics 14(5):333-338 |
| Davideau,J.L., Sahlberg,C., Blin,A., Papagerakis,P., Thesleff,I., and, Berdal,A. (1995) International Journal of Developmental Biology 39(4):605-615 |
| Miettinen,P.J., Berger,J.E., Meneses,J., Phung,Y., Pedersen,R.A., Werb,Z., and, Derynck,R. (1995) Nature 376(6538):337-341 |