Expression of dentin phosphoprotein in mouse tooth

DSPP (gene); DPP (protein); (Translation product of DSPP cleaved into dentin phosphoprotein (DPP) and dentin sialoprotein (DSP))

Species: mouse
Tooth: molar
Method: immunochemistry, antibody: monospecific polyclonal


Secretory stage
Expression: odontoblasts, predentin, dentin
No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, ameloblasts, enamel, dental papilla, dental sac

DPP is expressed from same transcript as dentin sialoprotein (DSP). DPP is believed to function in initiation of dentin mineralization.

Source references:
MacDougall,M., Zeichner-David,M., and, Slavkin,H.C. (1985) Biochemical Journal 232(2):493-500

Other references:
Bègue-Kirn,C., Krebsbach,P.H., Bartlett,J.D., and, Butler,W.T. (1998) European Journal of Oral Sciences 106:963-970
Butler,W.T., Bhown,M., DiMuzio,M.T., Cothran,W.C., and, Linde,A. (1983) Archives of Biochemistry & Biophysics 225(1):178-186
Stetler-Stevenson,W.G., and, Veis,A. (1983) Biochemistry 22(18):4326-4335
MacDougall,M., Simmons,D., Luan,X., Nydegger,J., Feng,J., and, Gu,T.T. (1997) Journal of Biological Chemistry 272(2):835-842

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Data last edited 20.02.1998 by M.P., page last created 10.12.2004 by P.N.