Expression of Dlx2 in mouse tooth

Dlx2; distal-less homeobox 2; Tes1

Species: mouse
Location in mouse genome: chromosome 2, 71884664 - 71887997 (UCSC, assembly October 2003)
Tooth: molar and incisor
Method: in situ hybridization (radioactive), probe: 576b


Initiation stage
Expression: dental epithelium, dental mesenchyme
No expression: oral epithelium

Bud stage
Expression: dental epithelium, dental mesenchyme
No expression: oral epithelium

Cap stage
Expression: outer enamel epithelium, inner enamel epithelium, dental papilla
No expression: oral epithelium, dental sac

Bell stage
Expression: outer enamel epithelium, inner enamel epithelium, stratum intermedia
No expression: oral epithelium, dental sac

Late bell (differentiation) stage
Expression: outer enamel epithelium, stratum intermedia, preameloblasts
No expression: dental papilla, dental sac, preodontoblasts

Drosophila relative: distalless.
Transgenic mice lacking both Dlx1 and Dlx2 genes do not develop maxillary molars. The development is arrested after initiation..

Source references:
Robinson,G.W., and, Mahon,K.A. (1994) Mechanisms of Development 48(3):199-215
Zhao,Z.Y., Stock,D.W., Buchanan,A.V., and, Weiss,K.M. (2000) Development Genes & Evolution 210(5):270-275

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Data last edited 13.10.2000 by M.P., page last created 10.12.2004 by P.N.