Expression of Dlx2 in mouse tooth |
| Dlx2; distal-less homeobox 2; Tes1 |
| Species: mouse |
| Location in mouse genome: chromosome 2, 71884664 - 71887997 (UCSC, assembly October 2003) |
| Tooth: molar and incisor |
| Method: immunochemistry, antibody: polyclonal, |
Initiation stage | |
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Expression: oral epithelium, dental epithelium, dental mesenchyme |
Bud stage | |
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Expression: dental epithelium, dental mesenchyme No expression: oral epithelium |
Cap stage | |
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Expression: outer enamel epithelium, inner enamel epithelium, enamel knot, stellate reticulum, dental papilla No expression: oral epithelium, basement membrane, dental sac | |
Bell stage | |
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Expression: outer enamel epithelium, inner enamel epithelium, stratum intermedia, stellate reticulum, dental papilla No expression: oral epithelium, basement membrane, dental sac | |
Late bell (differentiation) stage | |
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Expression: outer enamel epithelium, stratum intermedia, stellate reticulum, preameloblasts, dental papilla No expression: basement membrane, dental sac, preodontoblasts | |
| Transgenic mice lacking both Dlx1 and Dlx2 genes do not develop maxillary molars. The development is arrested after initiation.. |
| Drosophila relative: distalless. |
| Source references: |
| Thomas,B.L., Porteus,M.H., Rubenstein,J.L., and, Sharpe,P.T. (1995) Connective Tissue Research 32(1-4):27-34 |
| Other references: |
| Porteus,M.H., Bulfone,A., Ciaranello,R.D., and, Rubenstein,J.L. (1991) Neuron 7(2):221-229 |
| Bei,M., and, Maas,R. (1998) Development 125(21):4325-4333 |
| Porteus,M.H., Bulfone,A., Ciaranello,R.D., and, Rubenstein,J.L. (1991) Neuron 7(2):221-229 |