Expression of Dlx1 in mouse tooth

Dlx1; distal-less homeobox 1

Species: mouse
Location in mouse genome: chromosome 2, 71870700 - 71875236 (UCSC, assembly October 2003)
Tooth: molar
Method: in situ hybridization (radioactive), probe: 100b,900b

Bud stage
Expression: dental mesenchyme
No expression: oral epithelium, dental epithelium

Cap stage
Expression: dental papilla, dental sac
No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, enamel knot, stellate reticulum

Transgenic mice lacking both Dlx1 and Dlx2 genes do not develop maxillary molars. The development is arrested after initiation..
Drosophila relative: distalless.

Source references:
Dollé,P., Price,M., and, Duboule,D. (1992) Differentiation 49(2):93-99

Other references:
Bei,M., and, Maas,R. (1998) Development 125(21):4325-4333
Zhao,G.Q., Zhao,S., Zhou,X., Eberspaecher,H., Solursh,M., and, de Crombrugghe,B. (1994) Developmental Biology 164(1):37-51
Zhao,Z.Y., Stock,D.W., Buchanan,A.V., and, Weiss,K.M. (2000) Development Genes & Evolution 210(5):270-275

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Data last edited 13.10.2000 by M.P., page last created 10.12.2004 by P.N.