Expression of Ctgf/Fisp12 in mouse tooth

connective tissue growth factor; fibroblast-inducible secreted protein-12; beta-IG-M2; insulin like growth factor binding protein 8 (Igfbp8)

Species: mouse
Method: in situ hybridization (radioactive), immunochemistry, reagent: 160b;polyclonal


Initiation stage
Expression: dental epithelium
No expression: oral epithelium, dental mesenchyme

Bud stage
Expression: oral epithelium, dental epithelium, dental mesenchyme

Cap stage
Expression: enamel knot, dental sac
No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stellate reticulum, dental papilla

Bell stage
Expression: outer enamel epithelium, inner enamel epithelium, dental sac
No expression: oral epithelium, stratum intermedia, stellate reticulum, dental papilla

In addition by immunochemistry there was staining of the mesenchyme immediately below the epithelium..

Late bell
(differentiation) stage
Expression: outer enamel epithelium, preameloblasts, dental sac
No expression: stratum intermedia, stellate reticulum, dental papilla, preodontoblasts

Secretory stage
Expression: outer enamel epithelium, dental sac, odontoblasts
No expression: stratum intermedia, stellate reticulum, ameloblasts, dental papilla, predentin, dentin


Source references:
Shimo,T., Wu,C., Billings,P.C., Piddington,R., Rosenbloom,J., Pacifici,M., and, Koyama,E. (2002) Developmental Dynamics 224(3):267-278

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Data last edited 30.03.2004 by M.K., page last created 10.12.2004 by P.N.