Expression of Bmp7 in mouse tooth |
| Bmp7; bone morphogenetic protein 7; osteogenic protein 1 (OP-1); Dvr7 |
| Species: mouse |
| Location in mouse genome: chromosome 2, 173295248 - 173365852 (UCSC, assembly October 2003) |
| Tooth: lower molar |
| Method: in situ hybridization (radioactive), probe: 220b |
Initiation stage | |
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Expression: oral epithelium, dental epithelium No expression: dental mesenchyme |
Bud stage | |
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Expression: oral epithelium, dental epithelium No expression: dental mesenchyme |
Cap stage | |
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Expression: enamel knot No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stellate reticulum, dental papilla, dental sac Bmp7 expression is lost in the enamel knot in the Lef1 null mutant mouse (Kratochwil et al 2002). See expression of Lef1. Expression extends somewhat outside the enamel knot.. |
Bell stage | |
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Expression: inner enamel epithelium No expression: oral epithelium, outer enamel epithelium, stratum intermedia, stellate reticulum, dental papilla, dental sac |
Late bell (differentiation) stage | |
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Expression: preameloblasts, preodontoblasts No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, dental papilla, dental sac |
Secretory stage | |
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Expression: ameloblasts, odontoblasts No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, dental papilla, dental sac |
Root development | |
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Expression: dental papilla, odontoblasts No expression: cementoblasts The expression was in the early odontoblasts.. | |
| Source references: |
| Åberg,T., Wozney,J., and, Thesleff,I. (1997) Developmental Dynamics 210(4):383-396 |
| Yamashiro,T., Tummers,M., and, Thesleff,I. (2003) Journal of Dental Research 82(3):172-176 |
| Other references: |
| Helder,M.N., Karg,H., Bervoets,T.J., Vukicevic,S., Burger,E.H., D'Souza,R.N., Wöltgens,J.H., Karsenty,G., and, Bronckers,A.L. (1998) Journal of Dental Research 77(4):545-554 |