Expression of Bmp2 in mouse tooth |
Bmp2; bone morphogenetic protein 2; Bmp2a; Dvr2 |
Species: mouse |
Location in mouse genome: chromosome 2, 133695392 - 133704100 (UCSC, assembly October 2003) |
Tooth: lower molar |
Method: in situ hybridization (radioactive), probe: 240b |
Initiation stage | |
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Expression: dental epithelium No expression: oral epithelium, dental mesenchyme |
Bud stage | |
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Expression: dental epithelium No expression: oral epithelium, dental mesenchyme |
Cap stage | |
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Expression: enamel knot No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stellate reticulum, dental papilla, dental sac Bmp2 expression is lost in the enamel knot in the Lef1 null mutant mouse (Kratochwil et al 2002). See expression of Lef1. |
Bell stage | |
Expression: dental papilla No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stratum intermedia, stellate reticulum, dental sac | |
Late bell (differentiation) stage | |
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Expression: dental papilla, preodontoblasts No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, preameloblasts, dental sac |
Secretory stage | |
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Expression: ameloblasts, odontoblasts No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, dental papilla, dental sac During the first postnatal days (P2 to P4), transcripts disappear from the most advanced odontoblasts in the cuspal areas.. |
Root development | |
Expression: dental papilla, odontoblasts No expression: cementoblasts The expression was detected in the early odontoblasts.. |
Source references: |
Åberg,T., Wozney,J., and, Thesleff,I. (1997) Developmental Dynamics 210(4):383-396 |
Yamashiro,T., Tummers,M., and, Thesleff,I. (2003) Journal of Dental Research 82(3):172-176 |
Other references: |
Dassule,H.R., and, McMahon,A.P. (1998) Developmental Biology 202(2):215-227 |
Lyons,K.M., Pelton,R.W., and, Hogan,B.L.M. (1990) Development 109:833-844 |
Åberg,T., Wang,X.P., Kim,J.H., Yamashiro,T., Bei,M., Rice,R., Ryoo,H.M., and, Thesleff,I. (2004) Developmental Biology 270(1):76-93 |
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