Expression of amelogenin in mouse tooth

Amelx; Algn; Amg; Amgl

Species: mouse
Location in mouse genome: chromosome X, 157310884 - 157318072 (UCSC, assembly October 2003)
Tooth: lower molar
Method: immunochemistry, antibody: polyclonal

Late bell (differentiation) stage
Expression: preameloblasts
No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, basement membrane, dental papilla, dental sac, preodontoblasts

Secretory stage
Expression: ameloblasts, enamel
No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, dental papilla, dental sac, odontoblasts, predentin, dentin

Detected weakly in the apical half of the ameloblast cytoplasm..

By RT-PCR amelogenin transcripts demonstrated at cap stage (E15 mouse).
Located at the onset of enamel biomineralization.

Source references:
Diekwisch,T.G., Ware,J., Fincham,A.G., and, Zeichner-David,M. (1997) Journal of Histochemistry & Cytochemistry 45(6):859-866
Zeichner-David,M., Vo,H., Tan,H., Diekwisch,T., Berman,B., Thiemann,F., Alcocer,M.D., Hsu,P., Wang,T., Eyna,J., Caton,J., Slavkin,H.C., MacDougall, and, M. (1997) International Journal of Developmental Biology 41(1):27-38

Other references:
Couwenhoven,R.I., and, Snead,M.L. (1994) Developmental Biology 164(1):290-299
Nanci,A., Bendayan,M., and, Slavkin,H.C. (1985) Journal of Histochemistry & Cytochemistry 33(11):1153-1160
Slavkin,H.C., Zeichner-David,M., MacDougall,M., Bessem,C., Bringas,P., Honig,L.S., Lussky,J., and, Vides,J. (1982) Journal of Dental Research Spec No:1467-1471
Termine,J.D., Belcourt,A.B., Christner,P.J., Conn,K.M., and, Nylen,M.U. (1980) Journal of Biological Chemistry 255(20):9760-9768

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Data last edited 12.02.1998 by M.P., page last created 10.12.2004 by P.N.