Expression of Tabby in mouse tooth

ectodysplasin; EDA

Species: mouse
Method: in situ hybridization (radioactive), probe: 398nt

Cap stage
Expression: oral epithelium, outer enamel epithelium
No expression: inner enamel epithelium, enamel knot, stellate reticulum, dental papilla, dental sac

Tabby mouse has defects in teeth and skin (anhidrotic ectodermal dysplasia).
Tabby gene encodes a tumor necrosis factor family ligand ectodysplasin
Human homolog: EDA

Source references:
Srivastava,A.K., Pispa,J., Hartung,A.J., Du,Y., Ezer,S., Jenks,T., Shimada,T., Pekkanen,M., Mikkola,M., Ko,M.S.H., Thesleff,I., Kere,J., and Schlessinger,D. (1997) Proceedings of the National Academy of Sciences of the United States of America 94:13069-13074

Other references:
Mikkola,M.L., Pispa,J., Pekkanen,M., Paulin,L., Nieminen,P., Kere,J., and Thesleff,I. (1999) Mechanisms of Development 88(2):133-146
Tucker,A.S., Headon,D.J., Schneider,P., Ferguson,B.M., Overbeek,P., Tschopp, J, and Sharpe,P.T. (2000) Development 127(21):4691-4700

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Data last edited 30.11.1999 by P.N., page last edited 23.01.2001 by P.N.