Expression of Sonic hedgehog in mouse tooth |
| Shh; Dsh; Hhg1; short digits |
| Species: mouse |
| Location in mouse genome: chromosome 5, 26707815 - 26718063 (UCSC, assembly October 2003) |
| Tooth: lower molar |
| Method: in situ hybridization (radioactive), probe: |
Bud stage | |
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Expression: dental epithelium No expression: oral epithelium, dental mesenchyme |
Cap stage | |
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Expression: enamel knot No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stellate reticulum, dental papilla, dental sac Shh expression is lost in the enamel knot in the Lef1 null mutant mouse (Kratochwil et al 2002). See expression of Lef1. Shh expression was absent in the enamel knots of lower molars and reduced in the enamel knots of the upper molars in Runx2 null mutant mice (Åberg et al 2004). See expression of Runx2. |
Bell stage | |
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Expression: inner enamel epithelium No expression: oral epithelium, outer enamel epithelium, stratum intermedia, stellate reticulum, dental papilla, dental sac |
| Sonic hedgehog expression region is larger in presuumptive incisor epithelium in IKKA null mutant mouse. (Ohazama et al 2004) See expression of IKKA. |
| Source references: |
| Bitgood,M.J., and, McMahon,A.P. (1995) Developmental Biology 172(1):126-138 |
| Other references: |
| Dassule,H.R., and, McMahon,A.P. (1998) Developmental Biology 202(2):215-227 |
| Iseki,S., Araga,A., Ohuchi,H., Nohno,T., Yoshioka,H., Hayashi,F., and, Noji,S. (1996) Biochemical & Biophysical Research Communications 218(3):688-693 |
| Vaahtokari,A., Åberg,T., Jernvall,J., Keränen,S., and, Thesleff,I. (1996) Mechanisms of Development 54:39-43 |
| Motoyama,J., Takabatake,T., Takeshima,K., and, Hui,C. (1998) Nature Genetics 18(2):104-106 |