Expression of Sonic hedgehog in mouse tooth

Shh; Dsh; Hhg1; short digits

Species: mouse
Location in mouse genome: chromosome 5, 26707815 - 26718063 (UCSC, assembly October 2003)
Tooth: lower molar
Method: in situ hybridization (radioactive), probe:


Bud stage
Expression: dental epithelium
No expression: oral epithelium, dental mesenchyme

Cap stage
Expression: enamel knot
No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stellate reticulum, dental papilla, dental sac

Shh expression is lost in the enamel knot in the Lef1 null mutant mouse (Kratochwil et al 2002). See expression of Lef1.
Shh expression was absent in the enamel knots of lower molars and reduced in the enamel knots of the upper molars in Runx2 null mutant mice (Åberg et al 2004). See expression of Runx2.

Bell stage
Expression: inner enamel epithelium
No expression: oral epithelium, outer enamel epithelium, stratum intermedia, stellate reticulum, dental papilla, dental sac

Sonic hedgehog expression region is larger in presuumptive incisor epithelium in IKKA null mutant mouse. (Ohazama et al 2004) See expression of IKKA.

Source references:
Bitgood,M.J., and, McMahon,A.P. (1995) Developmental Biology 172(1):126-138

Other references:
Dassule,H.R., and, McMahon,A.P. (1998) Developmental Biology 202(2):215-227
Iseki,S., Araga,A., Ohuchi,H., Nohno,T., Yoshioka,H., Hayashi,F., and, Noji,S. (1996) Biochemical & Biophysical Research Communications 218(3):688-693
Vaahtokari,A., Åberg,T., Jernvall,J., Keränen,S., and, Thesleff,I. (1996) Mechanisms of Development 54:39-43
Motoyama,J., Takabatake,T., Takeshima,K., and, Hui,C. (1998) Nature Genetics 18(2):104-106


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Data last edited 07.10.1996 by M.P., page last created 10.12.2004 by P.N.