Nieminen,P., Arte,S., Pirinen,S., Peltonen,L., and, Thesleff,I.
Gene defect in hypodontia - exclusion of msx1 and msx2 as candidate genes.
Hum Genet 96(3):305-308 (1995).
Hypodontia, congenital lack of one or a few teeth, is an autosomally inherited dominant trait. Homeobox genes MSX1 and MSX2 are expressed in presumptive dental tissues at the stage of initiation of tooth development. Recently, tooth development was shown to be inhibited in transgenic mice lacking a functional Msxl gene. Here, we studied the relationship of the MSX1 and MSX2 genes to familial hypodontia in five Finnish families with a total of 20 affected individuals, by linkage analysis. The pairwise led-scores regarding the intragenic microsatellites in the MSX1 and MSX2 genes at a recombination fraction of 0.0 were - 3.1 and -3.0, respectively, thus excluding these genes as causative loci for hypodontia in these families. [References: 36].
Last edited 10.12.2004 by P.N.