Expression of Prrx2 in mouse tooth

Prrx2; paired related homeobox 2; Prx2; S8

Species: mouse
Tooth: molar and incisor
Method: in situ hybridization (radioactive), probe: 575nt, 200nt


Initiation stage
Expression: dental mesenchyme
No expression: oral epithelium, dental epithelium

Bud stage
Expression: dental mesenchyme
No expression: oral epithelium, dental epithelium

Cap stage
Expression: dental papilla, dental sac
No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, enamel knot, stellate reticulum

Bell stage
Expression: dental papilla, dental sac
No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stratum intermedia, stellate reticulum

Transgenic mice deficient in both Prx1 and Prx2 lack mandibular incisors. The development is arrested within bud stage as a single incisor bud..

Source references:
Opstelten,D.J., Vogels,R., Robert,B., Kalkhoven,E., Zwartkruis,F., de Laaf,L., Destrée,O.H., Deschamps,J., Lawson,K.A., and, Meijlink,F. (1991) Mechanisms of Development 34(1):29-41
Karg,H., Burger,E.H., Lyaruu,D.M., Bronckers,A.L., and, Wöltgens,J.H. (1997) Archives of Oral Biology 42(9):625-631
Lu,M.F., Cheng,H.T., Kern,M.J., Potter,S.S., Tran,B., Diekwisch,T.G.H., Martin, JF., Jmartin@ibt.tamu.edu, Paired-related homeobox, Craniofacial development, Genetic redundancy, Mouse, and, Prx-1. (1999) Development 126(3):495-504


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Data last edited 26.04.2004 by M.K., page last created 10.12.2004 by P.N.