Expression of Prrx1 in mouse tooth

Phox; Mhox; paired related homeobox 1 (Prx1); K2; paired mesoderm homeobox (Pmx)

Species: mouse
Tooth: molar and incisor
Method: whole mount in situ hybridization, probe:


Transgenic mice deficient in both prx1 and prx2 lack mandibular incisors. The development is arrested within bud stage as a single incisor bud..
Prx1 has similar expression pattern as prx2 (from ED 10.5 to 12.5).

Source references:
Lu,M.F., Cheng,H.T., Kern,M.J., Potter,S.S., Tran,B., Diekwisch,T.G.H., Martin, JF., Jmartin@ibt.tamu.edu, Paired-related homeobox, Craniofacial development, Genetic redundancy, Mouse, and, Prx-1. (1999) Development 126(3):495-504

Other references:
ten Berge,D., Brouwer,A., Korving,J., Martin,J.F., Meijlink,F., frits@niob.knaw.nl, Mouse, Homeobox gene, Gene targeting, Aristaless domain, Epitheliomesenchymal interaction, Craniofacial development, Limb, Inner, and, ear. (1998) Development 125(19):3831-3842


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Data last edited 05.04.2004 by M.K., page last created 10.12.2004 by P.N.