Expression of p21 in mouse tooth

Cdkn1a; cyclin dependent kinase inhibitor 1a; Waf1; p21Waf; p21Waf; Cip1; Cdk interactin protein 1; Mda6; Sdi1

Species: mouse
Tooth: molar
Method: in situ hybridization (radioactive), whole mount in situ hybridization, probe: 740 bp (ref 2)


Bud stage
Expression: dental epithelium
No expression: oral epithelium, dental mesenchyme

BMP4 (in beads) induces p21 expression in cultured dental epithelium (Jernvall et al 1998). See expression of Bmp4.

Cap stage
Expression: enamel knot
No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stellate reticulum, dental papilla, dental sac

Bell stage
Expression: inner enamel epithelium
No expression: oral epithelium, outer enamel epithelium, stratum intermedia, stellate reticulum, dental papilla, dental sac

Late bell
(differentiation) stage
Expression: preameloblasts, preodontoblasts
No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, dental papilla, dental sac

Similar expression in incisor.


Source references:
Bloch-Zupan,A., Leveillard,T., Gorry,P., Fausser,J.L., and, Ruch,J.V. (1998) European Journal of Oral Sciences 106(1):104-111
Jernvall,J., Åberg,T., Kettunen,P., Keranen,S., and, Thesleff,I. (1998) Development 125(2):161-169

Other references:
Åberg,T., Wang,X.P., Kim,J.H., Yamashiro,T., Bei,M., Rice,R., Ryoo,H.M., and, Thesleff,I. (2004) Developmental Biology 270(1):76-93


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Data last edited 01.11.2004 by P.N., page last created 10.12.2004 by P.N.