Expression of p21 in mouse tooth |
| Cdkn1a; cyclin dependent kinase inhibitor 1a; Waf1; p21Waf; p21Waf; Cip1; Cdk interactin protein 1; Mda6; Sdi1 |
| Species: mouse |
| Tooth: molar |
| Method: in situ hybridization (radioactive), whole mount in situ hybridization, probe: 740 bp (ref 2) |
Bud stage | |
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Expression: dental epithelium No expression: oral epithelium, dental mesenchyme BMP4 (in beads) induces p21 expression in cultured dental epithelium (Jernvall et al 1998). See expression of Bmp4. |
Cap stage | |
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Expression: enamel knot No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stellate reticulum, dental papilla, dental sac |
Bell stage | |
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Expression: inner enamel epithelium No expression: oral epithelium, outer enamel epithelium, stratum intermedia, stellate reticulum, dental papilla, dental sac |
Late bell (differentiation) stage | |
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Expression: preameloblasts, preodontoblasts No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, dental papilla, dental sac Similar expression in incisor. |
| Source references: |
| Bloch-Zupan,A., Leveillard,T., Gorry,P., Fausser,J.L., and, Ruch,J.V. (1998) European Journal of Oral Sciences 106(1):104-111 |
| Jernvall,J., Åberg,T., Kettunen,P., Keranen,S., and, Thesleff,I. (1998) Development 125(2):161-169 |
| Other references: |
| Åberg,T., Wang,X.P., Kim,J.H., Yamashiro,T., Bei,M., Rice,R., Ryoo,H.M., and, Thesleff,I. (2004) Developmental Biology 270(1):76-93 |