Expression of Msx2 in mouse tooth |
| Hox8; Msh (muscle segment homeobox) drosophila homolog 2 |
| Species: mouse |
| Location in mouse genome: chromosome 13, 53231176 - 53236365 (UCSC, assembly October 2003) |
| Tooth: lower molar |
| Method: in situ hybridization (radioactive), probe: 850b |
Initiation stage | |
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Expression: dental mesenchyme No expression: oral epithelium, dental epithelium BMP4 (in beads) induces Msx2 expression in cultured dental mesenchyme (Vainio et al 1993). See expression of Bmp4. |
Bud stage | |
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Expression: dental epithelium No expression: oral epithelium, dental mesenchyme BMP4 (in beads) induces Msx2 expression in cultured dental epithelium (Jernvall et al 1998). See expression of Bmp4. |
Cap stage | |
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Expression: outer enamel epithelium, inner enamel epithelium, enamel knot, stellate reticulum No expression: oral epithelium, dental papilla, dental sac |
Bell stage | |
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Expression: outer enamel epithelium, inner enamel epithelium, stratum intermedia, stellate reticulum, dental papilla No expression: oral epithelium, dental sac |
Late bell (differentiation) stage | |
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Expression: outer enamel epithelium, stratum intermedia, stellate reticulum, dental papilla, preodontoblasts No expression: preameloblasts, dental sac |
Root development | |
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Expression: odontoblasts, cementoblasts, periodontal ligament No expression: dental papilla | |
| In Msx1/Msx2 double knockout mice, tooth development is arrested either during the initiation stage or early bud stages. |
| Source references: |
| MacKenzie,A., Ferguson,M.W., and, Sharpe,P.T. (1992) Development 115(2):403-420 |
| Yamashiro,T., Tummers,M., and, Thesleff,I. (2003) Journal of Dental Research 82(3):172-176 |
| Other references: |
| Jowett,A.K., Vainio,S., Ferguson,M.W., Sharpe,P.T., and, Thesleff,I. (1993) Development 117(2):461-470 |
| Liu,Y.H., Ma,L., Wu,L.Y., Luo,W., Kundu,R., Sangiorgi,F., Snead,M.L., and, Maxson,R. (1994) Mechanisms of Development 48(3):187-197 |