Expression of Msx1 in mouse tooth |
| homeobox 7 (Hox7); Hox-7.1; Msh (muscle segment homeobox) drosophila homolog 1 |
| Species: mouse |
| Location in mouse genome: chromosome 5, 36201253 - 36205218 (UCSC, assembly October 2003) |
| Tooth: molar |
| Method: in situ hybridization (radioactive), probe: 900b |
Initiation stage | |
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Expression: dental mesenchyme No expression: oral epithelium, dental epithelium BMP4 (in beads) induces Msx1 expression in cultured dental mesenchyme (Vainio et al 1993). See expression of Bmp4. |
Bud stage | |
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Expression: dental mesenchyme No expression: oral epithelium, dental epithelium |
Cap stage | |
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Expression: dental papilla, dental sac No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, enamel knot, stellate reticulum |
Bell stage | |
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Expression: dental papilla, dental sac No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stratum intermedia, stellate reticulum |
Late bell (differentiation) stage | |
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Expression: dental papilla, dental sac, preodontoblasts No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, preameloblasts |
Secretory stage | |
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Expression: dental papilla, dental sac, odontoblasts No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, ameloblasts |
Root development | |
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Expression: dental papilla, odontoblasts, periodontal ligament No expression: cementoblasts | |
| In Msx1 null mutant mouse, teeth do not develop past bud stage. |
| In Msx1/Msx2 double knockout mice, tooth development is arrested either during the initiation stage or early bud stages. |
| Mutations in MSX1 cause severe congenital tooth agenesis, oligodontia. |
| Runx2 expression was absent in the mesenchyme in Msx1 null mutant mice. (Åberg et al 2004) See expression of Runx2. |
| Msx1 expression was reduced in the dental mesenchyme in Pax9 null mutant mice. (Peters et al 1998) See expression of Pax9. |
| Source references: |
| MacKenzie,A., Ferguson,M.W., and, Sharpe,P.T. (1992) Development 115(2):403-420 |
| Yamashiro,T., Tummers,M., and, Thesleff,I. (2003) Journal of Dental Research 82(3):172-176 |
| Other references: |
| Satokata,I., and, Maas,R. (1994) Nature Genetics 6(4):348-356 |
| Vastardis,H., Karimbux,N., Guthua,S.W., Seidman,J.G., and, Seidman,C.E. (1996) Nature Genetics 13(4):417-421 |
| Åberg,T., Wang,X.P., Kim,J.H., Yamashiro,T., Bei,M., Rice,R., Ryoo,H.M., and, Thesleff,I. (2004) Developmental Biology 270(1):76-93 |