Witkop syndrome

Dysplasia of nails together with hypodontia was first described by (Witkop et al, 1965). This syndrome is inherited in an autosomal dominant manner. Fingernails and especially toenails are dysplastic in childhood. Mandibular incisors, second molars, and maxillary canines are the teeth most often missing or having conical crowns. Some patients show hypodontia or a conical form of primary teeth.

Text adapted from Sirpa Arte: Phenotypic and genotypic features of familial hypodontia. Dissertation, Institute of Dentistry, University of Helsinki, Finland, 2001.

Jackson Mouse Genome Database Transgene Database OMIM

Text last edited 09.10.2003 by P.N. , page last created 10.12.2004 by P.N.