Expression of Hgf in mouse tooth

hepatocyte growth factor; scatter factor (Sf); lung fibroblast derived mitogen; hepatopoietin A

Species: mouse
Location in mouse genome: chromosome 5, 14486998 - 14552413 (UCSC, assembly October 2003)
Tooth: molar
Method: in situ hybridization (radioactive), probe: 449b


Cap stage
No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, enamel knot, stellate reticulum, dental papilla, dental sac

Bell stage
Expression: dental papilla
No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stratum intermedia, stellate reticulum, dental sac

Late bell
(differentiation) stage
Expression: dental papilla
No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, preameloblasts, dental sac, preodontoblasts

HGF is the ligand of the c-met receptor.
Antisense inhibition of HGF in vitro results in impaired tooth morphogenesis (Tabata et al., 1996).

Source references:
Sonnenberg,E., Weidner,K.M., and, Birchmeier,C. (1993) EXS 65:381-394

Other references:
Tabata,M.J., Kim,K., Yamashita,K., Matsumura,T., Kato,J., Iwamoto,M., Walkisaka,S., Matsumoto,K., Nakamura,T., Kumegawa,M., and, Kurisu,K. (1996) Development 122:1243-1251

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Data last edited 31.03.2004 by M.K., page last created 10.12.2004 by P.N.