Expression of Gli2 in mouse tooth

Species: mouse
Tooth: molar and incisor
Method: in situ hybridization (radioactive), probe:


Initiation stage
Expression: oral epithelium, dental epithelium, dental mesenchyme

Bud stage
Expression: oral epithelium, dental epithelium, dental mesenchyme

Cap stage
Expression: dental sac
No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, enamel knot, stellate reticulum, dental papilla

In the molars weak expression also in the epithelial component..
In the incisors expression was in the mesenchyme..

Tooth development is arrested after initiation in transgenic mice lacking both Gli2 and Gli3..

Source references:
Hardcastle,Z., Mo,R., Hui,C.C., and, Sharpe,P.T. (1998) Development 125(15):2803-2811

Other references:
Dassule,H.R., and, McMahon,A.P. (1998) Developmental Biology 202(2):215-227

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Data last edited 24.03.1999 by M.P., page last created 10.12.2004 by P.N.