Expression of Gdnf in mouse tooth

Glial cell line-derived neurotrophic factor

Species: mouse
Location in mouse genome: chromosome 15, 7256374 - 7282964 (UCSC, assembly October 2003)
Tooth: lower molar
Method: in situ hybridization (radioactive), probe:


Bud stage
No expression: oral epithelium, dental epithelium, dental mesenchyme

Expression was at the jaw mesenchyme surrounding the condensed dental mesenchyme..

Cap stage
Expression: dental sac
No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, enamel knot, stellate reticulum, dental papilla

Distribution between reports.

Late bell
(differentiation) stage
Expression: dental papilla, dental sac, preodontoblasts
No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, preameloblasts

Secretory stage
Expression: dental papilla, odontoblasts
No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, ameloblasts, dental sac


Source references:
Luukko,K., Suvanto,P., Saarma,M., and, Thesleff,I. (1997) Developmental Dynamics 210(4):463-471

Other references:
Hellmich,H.L., Kos,L., Cho,E.S., Mahon,C.A., and, Zimmer,A. (1996) Mechanisms of Development 54:95-105

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Data last edited 09.03.1998 by M.P., page last created 10.12.2004 by P.N.