Expression of Fgfr2(IIIb) in mouse tooth

fibroblast growth factor receptor 2 III b; Kgfr

Species: mouse
Tooth: lower molar and incisor
Method: in situ hybridization (radioactive), probe: 150b,139b


Initiation stage
Expression: oral epithelium, dental epithelium
No expression: dental mesenchyme

Bud stage
Expression: oral epithelium, dental epithelium
No expression: dental mesenchyme

Cap stage
Expression: oral epithelium, outer enamel epithelium, stellate reticulum
No expression: inner enamel epithelium, enamel knot, dental papilla, dental sac

Bell stage
Expression: oral epithelium, outer enamel epithelium, stratum intermedia, stellate reticulum
No expression: inner enamel epithelium, dental papilla, dental sac

Late bell
(differentiation) stage
Expression: outer enamel epithelium, stratum intermedia, stellate reticulum, preameloblasts
No expression: dental papilla, dental sac, preodontoblasts

Secretory stage
Expression: outer enamel epithelium, stellate reticulum
No expression: stratum intermedia, ameloblasts, dental papilla, dental sac, odontoblasts

Tooth development is arrested in transgenic mice expressing soluble Fgf-receptor ( Celli et al 1998).

Source references:
Kettunen,P., Karavanova,I., and, Thesleff,I. (1998) Developmental Genetics 22(4):374-385
Orr-Urtreger,A., Bedford,M.T., Burakova,T., Arman,E., Zimmer,Y., Yayon,A., Givol,D., and, Lonai,P. (1993) Developmental Biology 158(2):475-486


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Data last edited 30.03.1999 by M.P., page last created 10.12.2004 by P.N.