Expression of Fgf4 in mouse tooth

fibroblast growth factor 4; kaposi sarcoma oncogene (Kfgf); heparin secretory transforming protein 1 (Hstf1); oncogene Hst

Species: mouse
Location in mouse genome: chromosome 7, 136923512 - 136924949 (UCSC, assembly October 2003)
Tooth: lower molar and incisor
Method: in situ hybridization (radioactive), probe: 620b,


Initiation stage
No expression: oral epithelium, dental epithelium, dental mesenchyme

Bud stage
Expression: dental epithelium
No expression: oral epithelium, dental mesenchyme

Cap stage
Expression: enamel knot
No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stellate reticulum, dental papilla, dental sac

Expression was in enamel knots..
In incisors expression was not seen after cap stage..
Fgf4 expression is lost in the enamel knot in the Lef1 null mutant mouse (Kratochwil et al 2002). See expression of Lef1.
Fgf4 expression is a direct target of and positively regulated by Lef1 (Kratochwil et al 2002). See expression of Lef1.
FGF4 (in beads) induce Fgf3 expression in cultured dental mesenchyme (Kratochwil et al 2002). See expression of Fgf3.

Bell stage
Expression: inner enamel epithelium
No expression: oral epithelium, outer enamel epithelium, stratum intermedia, stellate reticulum, dental papilla, dental sac

Expression was in enamel knots..

Late bell
(differentiation) stage
No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, preameloblasts, dental papilla, dental sac, preodontoblasts

Expression was in enamel knots..


Source references:
Kettunen,P., and, Thesleff,I. (1998) Developmental Dynamics 211(3):256-268
Jernvall,J., Kettunen,P., Karavanova,I., Martin,L.B., and, Thesleff,I. (1994) International Journal of Developmental Biology 38(3):463-469

Other references:
Vaahtokari,A., Åberg,T., and, Thesleff,I. (1996) Development 122(1):121-129
Åberg,T., Wang,X.P., Kim,J.H., Yamashiro,T., Bei,M., Rice,R., Ryoo,H.M., and, Thesleff,I. (2004) Developmental Biology 270(1):76-93


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Data last edited 30.03.2004 by M.K., page last created 10.12.2004 by P.N.