Expression of EGFR in human tooth

epidermal growth factor receptor; ERBB1

Species: human
Location in human genome: chromosome 7, 54828553 - 55016774 (UCSC, assembly October 2003)
Method: in situ hybridization (radioactive), probe: 1,84kb


Cap stage
Expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, dental sac
No expression: enamel knot, stellate reticulum, basement membrane, dental papilla

Bell stage
Expression: outer enamel epithelium, inner enamel epithelium, stratum intermedia, dental sac
No expression: oral epithelium, stellate reticulum, basement membrane, dental papilla

Late bell
(differentiation) stage
Expression: outer enamel epithelium, stratum intermedia
No expression: stellate reticulum, preameloblasts, basement membrane, dental papilla, dental sac, preodontoblasts

Stellate reticulum negative by RISH and positive by immunocytochemistry..

Secretory stage
Expression: outer enamel epithelium, stratum intermedia
No expression: stellate reticulum, ameloblasts, enamel, dental papilla, dental sac, odontoblasts, predentin

Stellate reticulum negative by RISH and weakly positive by immunocytochemistry..
Expression lost in epithelium as matrix deposition progresses.

No dental defects noted in transgenic mice lacking EgfR expression (Miettinen et al., 1995).
Discrepancy between reports.

Source references:
Heikinheimo,K., Voutilainen,R., Happonen,R.P., and, Miettinen,P.J. (1993) International Journal of Developmental Biology 37(3):387-396

Other references:
Cobo,J., Hernández,L.C., del Valle,M.E., Vijande,M., and, Vega,J.A. (1992) European Journal of Orthodontics 14(5):333-338
Davideau,J.L., Sahlberg,C., Blin,A., Papagerakis,P., Thesleff,I., and, Berdal,A. (1995) International Journal of Developmental Biology 39(4):605-615
Miettinen,P.J., Berger,J.E., Meneses,J., Phung,Y., Pedersen,R.A., Werb,Z., and, Derynck,R. (1995) Nature 376(6538):337-341


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Data last edited 07.10.1996 by M.P., page last created 10.12.2004 by P.N.