Expression of Lef1 in vole tooth

expression of lymphoid enhancer factor 1 in diastema bud; lymphoid enhancer binding factor 1; transcription factor, T-cell specific, 1 alpha (Tcf1 alpha)

Species: vole
Tooth: diastema bud
Method: in situ hybridization (radioactive), probe: murine 660b


Initiation stage
Expression: dental epithelium, dental mesenchyme
No expression: oral epithelium

Bud stage
Expression: dental epithelium, dental mesenchyme
No expression: oral epithelium

Mouse null mutants of Lef1 do not develop teeth.
Lef1expression in the enamel knot is necessary for tooth development.

Source references:
Keränen,S.V.E., Kettunen,P., Åberg,T., Thesleff,I., and, Jernvall,J. (1999) Development Genes & Evolution 209(8):495-506


To the top of the page Titlepage mouse, mRNA vole, mRNA mouse, mRNA Send your comments
Pubmed Genbank Jackson Mouse Genome Database OMIM

Data last edited 05.04.2004 by M.K., page last created 10.12.2004 by P.N.