Expression of Lef1 in vole tooth |
| expression of lymphoid enhancer factor 1 in diastema bud; lymphoid enhancer binding factor 1; transcription factor, T-cell specific, 1 alpha (Tcf1 alpha) |
| Species: vole |
| Tooth: diastema bud |
| Method: in situ hybridization (radioactive), probe: murine 660b |
Initiation stage | |
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Expression: dental epithelium, dental mesenchyme No expression: oral epithelium | |
Bud stage | |
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Expression: dental epithelium, dental mesenchyme No expression: oral epithelium | |
| Mouse null mutants of Lef1 do not develop teeth. |
| Lef1expression in the enamel knot is necessary for tooth development. |
| Source references: |
| Keränen,S.V.E., Kettunen,P., Åberg,T., Thesleff,I., and, Jernvall,J. (1999) Development Genes & Evolution 209(8):495-506 |
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| Pubmed | Genbank | Jackson Mouse Genome Database | OMIM |