Expression of dentin sialophosphoprotein in mouse tooth

DSPP; (Translation product cleaved into dentin phosphoprotein (DPP) and dentin sialoprotein (DSP))

Species: mouse
Location in mouse genome: chromosome 5, 15288364 - 15293737 (UCSC, assembly October 2003)
Tooth: molar
Method: in situ hybridization (radioactive), probe:


Late bell
(differentiation) stage
Expression: preameloblasts, preodontoblasts
No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, dental papilla, dental sac

Secretory stage
Expression: odontoblasts
No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, ameloblasts, dental papilla, dental sac

DSPP gene codes for dentin sialoprotein and dentin phosphoprotein.
DSPP is highly specific for the odontoblast lineage.
Mutations in DSPP cause dentin dysplasia type II or dentinogenesis imperfecta type II.
Dentin defects in DSPP -/- mice resemble dentinogenesis imperfecta type III.

Source references:
Bègue-Kirn,C., Krebsbach,P.H., Bartlett,J.D., and, Butler,W.T. (1998) European Journal of Oral Sciences 106:963-970

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Data last edited 22.03.1999 by M.P., page last created 10.12.2004 by P.N.