Expression of Dlx3 in mouse tooth

Dlx3; distal-less homeobox 3

Species: mouse
Location in mouse genome: chromosome 11, 94703748 - 94708897 (UCSC, assembly October 2003)
Tooth: molar and incisor
Method: in situ hybridization (radioactive), probe: 1,1kb


Initiation stage
No expression: oral epithelium, dental epithelium, dental mesenchyme

Bud stage
Expression: dental mesenchyme
No expression: oral epithelium, dental epithelium

Epithelium positive in incisor bud..

Cap stage
Expression: dental papilla
No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, enamel knot, stellate reticulum, dental sac

Bell stage
Expression: inner enamel epithelium, dental papilla
No expression: oral epithelium, outer enamel epithelium, stratum intermedia, stellate reticulum, dental sac

Late bell (differentiation) stage
Expression: preameloblasts, dental papilla, preodontoblasts
No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, dental sac

Drosophila relative: distalless.
Mutations in DLX3 cause trichodentoosseous syndrome.

Source references:
Robinson,G.W., and, Mahon,K.A. (1994) Mechanisms of Development 48(3):199-215

Other references:
Weiss,K.M., Bollekens,J., Ruddle,F.H., and, Takashita,K. (1994) Journal of Experimental Zoology 270(3):273-284
Zhao,Z.Y., Stock,D.W., Buchanan,A.V., and, Weiss,K.M. (2000) Development Genes & Evolution 210(5):270-275


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Data last edited 07.10.1996 by M.P., page last created 10.12.2004 by P.N.