Expression of Bmp7 in mouse, rat, hamster tooth

Bmp7; bone morphogenetic protein 7; Dvr7; osteogenic protein 1 (OP-1)

Species: mouse, rat, hamster
Location in mouse genome: chromosome 2, 173295248 - 173365852 (UCSC, assembly October 2003)
Tooth: molar and incisor
Method: immunochemistry, antibody: affinity purified and monoclonals


Initiation stage
Expression: oral epithelium, dental epithelium, dental mesenchyme
No expression: basement membrane

Bud stage
Expression: oral epithelium, dental epithelium
No expression: basement membrane, dental mesenchyme

Cap stage
Expression: oral epithelium, inner enamel epithelium, stellate reticulum
No expression: outer enamel epithelium, basement membrane, dental papilla, dental sac

Bell stage
Expression: oral epithelium, inner enamel epithelium, stratum intermedia, stellate reticulum, dental papilla
No expression: outer enamel epithelium, basement membrane, dental sac

Late bell
(differentiation) stage
Expression: preameloblasts, preodontoblasts
No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, basement membrane, dental papilla, dental sac

Secretory stage
Expression: stratum intermedia, ameloblasts, enamel, odontoblasts, predentin, dentin
No expression: outer enamel epithelium, stellate reticulum, dental papilla, dental sac

Root development
Expression: odontoblasts, predentin, cementoblasts
No expression: dental papilla, dentin, cementum, periodontal ligament


Source references:
Helder,M.N., Karg,H., Bervoets,T.J., Vukicevic,S., Burger,E.H., D'Souza,R.N., Wöltgens,J.H., Karsenty,G., and, Bronckers,A.L. (1998) Journal of Dental Research 77(4):545-554


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Data last edited 09.03.1999 by M.P., page last created 10.12.2004 by P.N.