Expression of Bmp7 in mouse tooth

Bmp7; bone morphogenetic protein 7; osteogenic protein 1 (OP-1); Dvr7

Species: mouse
Location in mouse genome: chromosome 2, 173295248 - 173365852 (UCSC, assembly October 2003)
Tooth: lower molar
Method: in situ hybridization (radioactive), probe: 220b


Initiation stage
Expression: oral epithelium, dental epithelium
No expression: dental mesenchyme

Bud stage
Expression: oral epithelium, dental epithelium
No expression: dental mesenchyme

Cap stage
Expression: enamel knot
No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stellate reticulum, dental papilla, dental sac

Bmp7 expression is lost in the enamel knot in the Lef1 null mutant mouse (Kratochwil et al 2002). See expression of Lef1.
Expression extends somewhat outside the enamel knot..

Bell stage
Expression: inner enamel epithelium
No expression: oral epithelium, outer enamel epithelium, stratum intermedia, stellate reticulum, dental papilla, dental sac

Late bell
(differentiation) stage
Expression: preameloblasts, preodontoblasts
No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, dental papilla, dental sac

Secretory stage
Expression: ameloblasts, odontoblasts
No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, dental papilla, dental sac

Root development
Expression: dental papilla, odontoblasts
No expression: cementoblasts

The expression was in the early odontoblasts..


Source references:
Åberg,T., Wozney,J., and, Thesleff,I. (1997) Developmental Dynamics 210(4):383-396
Yamashiro,T., Tummers,M., and, Thesleff,I. (2003) Journal of Dental Research 82(3):172-176

Other references:
Helder,M.N., Karg,H., Bervoets,T.J., Vukicevic,S., Burger,E.H., D'Souza,R.N., Wöltgens,J.H., Karsenty,G., and, Bronckers,A.L. (1998) Journal of Dental Research 77(4):545-554


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Data last edited 10.11.2003 by M.K., page last created 10.12.2004 by P.N.