Expression of BMP-4 in cap stage mouse molar.
Courtesy of Thomas Åberg

Expression of Bmp4 in mouse tooth

Bmp4; bone morphogenetic protein 4; Bmp2b; Dvr4; Bmp2b1

Species: mouse
Location in mouse genome: chromosome 14, 38129874 - 38133204 (UCSC, assembly October 2003)
Tooth: lower molar
Method: in situ hybridization (radioactive), probe: 285b


Initiation stage
Expression: oral epithelium, dental epithelium, dental mesenchyme

Before the dental lamina stage the expression only in the oral epithelium..
BMP4 (in beads) induces Msx1 expression in cultured dental mesenchyme (Vainio et al 1993). See expression of Msx1.
BMP4 (in beads) induces Msx2 expression in cultured dental mesenchyme (Vainio et al 1993). See expression of Msx2.
BMP4 (in beads) repressed induction of Pax9 by FGF8 (in beads) in dental mesenchyme in tissue culture (Neubüser et al 1997). See expression of Pax9.

Bud stage
Expression: dental mesenchyme
No expression: oral epithelium, dental epithelium

Bmp4 expression was stronger on buccal side..
BMP4 (in beads) induces p21 expression in cultured dental epithelium (Jernvall et al 1998). See expression of p21.
BMP4 (in beads) induces Msx2 expression in cultured dental epithelium (Jernvall et al 1998). See expression of Msx2.

Cap stage
Expression: enamel knot, dental papilla, dental sac
No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stellate reticulum

Bmp4 expression was stronger on buccal side..
Bmp4 expression is lost in the enamel knot in the Lef1 null mutant mouse (Kratochwil et al 2002). See expression of Lef1.

Bell stage
Expression: dental papilla
No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stratum intermedia, stellate reticulum, dental sac

Late bell
(differentiation) stage
Expression: dental papilla, preodontoblasts
No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, preameloblasts, dental sac

Secretory stage
Expression: ameloblasts, odontoblasts
No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, dental papilla, dental sac

Root development
Expression: dental papilla, odontoblasts
No expression: cementoblasts

The expression was in the pre-odontoblasts..

Bmp4 expression was reduced in the dental mesenchyme in Pax9 null mutant mice. (Peters et al 1998) See expression of Pax9.

Source references:
Åberg,T., Wozney,J., and, Thesleff,I. (1997) Developmental Dynamics 210(4):383-396
Yamashiro,T., Tummers,M., and, Thesleff,I. (2003) Journal of Dental Research 82(3):172-176

Other references:
Bitgood,M.J., and, McMahon,A.P. (1995) Developmental Biology 172(1):126-138
Vaahtokari,A., Åberg,T., Jernvall,J., Keränen,S., and, Thesleff,I. (1996) Mechanisms of Development 54:39-43
Weiss,K.M., Bollekens,J., Ruddle,F.H., and, Takashita,K. (1994) Journal of Experimental Zoology 270(3):273-284
Åberg,T., Wang,X.P., Kim,J.H., Yamashiro,T., Bei,M., Rice,R., Ryoo,H.M., and, Thesleff,I. (2004) Developmental Biology 270(1):76-93


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Data last edited 10.11.2003 by M.K., page last created 10.12.2004 by P.N.