| Expression of BMP-4 in cap stage mouse molar. Courtesy of Thomas Åberg |  |
| Expression of BMP-4 in cap stage mouse molar. Courtesy of Thomas Åberg | |
Expression of Bmp4 in mouse tooth |
| Bmp4; bone morphogenetic protein 4; Bmp2b; Dvr4; Bmp2b1 |
| Species: mouse |
| Location in mouse genome: chromosome 14, 38129874 - 38133204 (UCSC, assembly October 2003) |
| Tooth: lower molar |
| Method: in situ hybridization (radioactive), probe: 285b |
Initiation stage | |
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Expression: oral epithelium, dental epithelium, dental mesenchyme Before the dental lamina stage the expression only in the oral epithelium.. BMP4 (in beads) induces Msx1 expression in cultured dental mesenchyme (Vainio et al 1993). See expression of Msx1. BMP4 (in beads) induces Msx2 expression in cultured dental mesenchyme (Vainio et al 1993). See expression of Msx2. BMP4 (in beads) repressed induction of Pax9 by FGF8 (in beads) in dental mesenchyme in tissue culture (Neubüser et al 1997). See expression of Pax9. |
Bud stage | |
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Expression: dental mesenchyme No expression: oral epithelium, dental epithelium Bmp4 expression was stronger on buccal side.. BMP4 (in beads) induces p21 expression in cultured dental epithelium (Jernvall et al 1998). See expression of p21. BMP4 (in beads) induces Msx2 expression in cultured dental epithelium (Jernvall et al 1998). See expression of Msx2. |
Cap stage | |
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Expression: enamel knot, dental papilla, dental sac No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stellate reticulum Bmp4 expression was stronger on buccal side.. Bmp4 expression is lost in the enamel knot in the Lef1 null mutant mouse (Kratochwil et al 2002). See expression of Lef1. |
Bell stage | |
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Expression: dental papilla No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stratum intermedia, stellate reticulum, dental sac |
Late bell (differentiation) stage | |
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Expression: dental papilla, preodontoblasts No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, preameloblasts, dental sac |
Secretory stage | |
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Expression: ameloblasts, odontoblasts No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, dental papilla, dental sac |
Root development | |
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Expression: dental papilla, odontoblasts No expression: cementoblasts The expression was in the pre-odontoblasts.. | |
| Bmp4 expression was reduced in the dental mesenchyme in Pax9 null mutant mice. (Peters et al 1998) See expression of Pax9. |
| Source references: |
| Åberg,T., Wozney,J., and, Thesleff,I. (1997) Developmental Dynamics 210(4):383-396 |
| Yamashiro,T., Tummers,M., and, Thesleff,I. (2003) Journal of Dental Research 82(3):172-176 |
| Other references: |
| Bitgood,M.J., and, McMahon,A.P. (1995) Developmental Biology 172(1):126-138 |
| Vaahtokari,A., Åberg,T., Jernvall,J., Keränen,S., and, Thesleff,I. (1996) Mechanisms of Development 54:39-43 |
| Weiss,K.M., Bollekens,J., Ruddle,F.H., and, Takashita,K. (1994) Journal of Experimental Zoology 270(3):273-284 |
| Åberg,T., Wang,X.P., Kim,J.H., Yamashiro,T., Bei,M., Rice,R., Ryoo,H.M., and, Thesleff,I. (2004) Developmental Biology 270(1):76-93 |
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