Expression of Bmp2 in mouse tooth

Bmp2; bone morphogenetic protein 2; Bmp2a; Dvr2

Species: mouse
Location in mouse genome: chromosome 2, 133695392 - 133704100 (UCSC, assembly October 2003)
Tooth: lower molar
Method: in situ hybridization (radioactive), probe: 240b


Initiation stage
Expression: dental epithelium
No expression: oral epithelium, dental mesenchyme

Bud stage
Expression: dental epithelium
No expression: oral epithelium, dental mesenchyme

Cap stage
Expression: enamel knot
No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stellate reticulum, dental papilla, dental sac

Bmp2 expression is lost in the enamel knot in the Lef1 null mutant mouse (Kratochwil et al 2002). See expression of Lef1.

Bell stage
Expression: dental papilla
No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stratum intermedia, stellate reticulum, dental sac

Late bell
(differentiation) stage
Expression: dental papilla, preodontoblasts
No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, preameloblasts, dental sac

Secretory stage
Expression: ameloblasts, odontoblasts
No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, dental papilla, dental sac

During the first postnatal days (P2 to P4), transcripts disappear from the most advanced odontoblasts in the cuspal areas..

Root development
Expression: dental papilla, odontoblasts
No expression: cementoblasts

The expression was detected in the early odontoblasts..


Source references:
Åberg,T., Wozney,J., and, Thesleff,I. (1997) Developmental Dynamics 210(4):383-396
Yamashiro,T., Tummers,M., and, Thesleff,I. (2003) Journal of Dental Research 82(3):172-176

Other references:
Dassule,H.R., and, McMahon,A.P. (1998) Developmental Biology 202(2):215-227
Lyons,K.M., Pelton,R.W., and, Hogan,B.L.M. (1990) Development 109:833-844
Åberg,T., Wang,X.P., Kim,J.H., Yamashiro,T., Bei,M., Rice,R., Ryoo,H.M., and, Thesleff,I. (2004) Developmental Biology 270(1):76-93


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Data last edited 10.11.2003 by M.K., page last created 10.12.2004 by P.N.