Expression of activin beta A in mouse tooth

Inhba; Inhba; inhibin/activin beta A; inhibin/activin betaA; follicle-stimulating hormone-releasing protein; follicle-stimulating hormone releasing protein; Frp; Frp; FSH releasing protein; FSH-releasing protein; FSH releasi
Species: mouse
Location in mouse genome: chromosome X, 96048655 - 96065874 (UCSC, assembly October 2003)
Tooth: molar
Method: in situ hybridization (radioactive), probe: 381 nt


Initiation stage
Expression: dental mesenchyme
No expression: oral epithelium, dental epithelium

Bud stage
Expression: dental mesenchyme
No expression: oral epithelium, dental epithelium

Cap stage
Expression: dental papilla
No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, enamel knot, stellate reticulum

Bell stage
Expression: dental papilla, dental sac
No expression: oral epithelium, outer enamel epithelium, inner enamel epithelium, stratum intermedia, stellate reticulum

Late bell (differentiation) stage
No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, preameloblasts, dental papilla, dental sac, preodontoblasts

Secretory stage
No expression: outer enamel epithelium, stratum intermedia, stellate reticulum, ameloblasts, dental papilla, dental sac, odontoblasts

Activin (in beads) induced EDAR expression in epithelium. (Laurikkala et al 2001) See expression of Edar.
Partial failure in tooth development in transgenic mice deficient in Activin beta A.

Source references:
Ferguson,C.A., Tucker,A.S., Christensen,L., Lau,A.L., Matzuk,M.M., and, Sharpe,P.T. (1998) Genes & Development 12(16):2636-2649
Heikinheimo,K., Bègue-Kirn,C., Ritvos,O., Tuuri,T., and, Ruch,J.V. (1997) Journal of Dental Research 76(10):1625-1636

Other references:
Åberg,T., Wang,X.P., Kim,J.H., Yamashiro,T., Bei,M., Rice,R., Ryoo,H.M., and, Thesleff,I. (2004) Developmental Biology 270(1):76-93


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Data last edited 24.03.2004 by M.K., page last created 10.12.2004 by P.N.